Navigating Challenges in PBC Management: Focus on Inadequate Responders and Symptomatic Itching

In this case study module, Marlyn Mayo discusses 3 short patient profiles to illustrate difficult situations when treating patients with PBC including managing inadequate response to initial therapy and symptomatic itching.

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General Information

Title: Navigating Challenges in PBC Management: Focus on Inadequate Responders and Symptomatic Itching

Jointly provided by Postgraduate Institute for Medicine and Springer Healthcare IME
This activity is supported by an independent educational grant from Ipsen

Release date: September 18th 2024

Expiration date: September 18th 2025

Estimated time to complete activity: 15 minutes

Target Audience

This activity is primarily aimed at a global audience of hepatologists and gastroenterologists, and is relevant to all members of the multidisciplinary team that manages PBC patients.

Educational Objectives

After completing this activity, the participant should be better able to:

  • Review the criteria for early and accurate diagnosis of PBC
  • Evaluate indications for starting second-line therapy in PBC patients
  • Apply strategies for improving the management of pruritus in PBC patients

Faculty

  • Marlyn Mayo
    Professor in the Department of Internal Medicine, Division of Digestive and Liver Diseases at the University of Texas Southwestern Medical Center, USA. 

Disclosure of Conflicts of Interest

Postgraduate Institute for Medicine (PIM) requires faculty, planners, and others in control of educational content to disclose all their financial relationships with ineligible companies. All identified conflicts of interest (COI) are thoroughly mitigated according to PIM policy.  PIM is committed to providing its learners with high quality accredited continuing education activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships with ineligible entities related to the educational content of this CE activity. These relationships have been mitigated:

  • Marlyn Mayo
    Grant/Research Support: CymaBay, Ipsen, Glaxo-Smith Kline, Mirum
    Consultant/Advisory Board: CymaBay, Glaxo-Smith Kline, Ipsen

The PIM planners and others have nothing to disclose. The Springer Healthcare IME planners and others have nothing to disclose.

Joint Accreditation Statement

In support of improving patient care, this activity has been planned and implemented by the Postgraduate Institute for Medicine and Springer Healthcare IME.  Postgraduate Institute for Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Credit Designation

Physician Continuing Medical Education

The Postgraduate Institute for Medicine designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA.  The planners of this activity do not recommend the use of any agent outside of the labeled indications.  The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners.  Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development.  The information presented in this activity is not meant to serve as a guideline for patient management.  Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

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