EASL 2026 Reflections: Key takeaways in late-onset genetic cholestasis and Alagille syndrome

Dr Silvia Vilarinho and Dr Deepak Joshi reflect on the highlights from EASL Congress 2026, focusing on late‑onset genetic cholestasis and new insights in Alagille syndrome. They discuss the expanding role of genomic testing in adults, the move toward multidisciplinary Genetic Grand Rounds, and emerging IBAT‑targeted therapies and pregnancy data that are changing diagnosis and management.
Diagnosing and managing late-onset genetic cholestasis: a clinical pathway tool

A practical algorithm tool to help you navigate the different clinical presentations, reach an accurate diagnosis, and take optimal first management steps.
EASL guidelines offer ‘framework’ for intrahepatic cholestasis of pregnancy care

Research confirms that the EASL guidelines aid risk stratification for intrahepatic cholestasis of pregnancy.
Intrahepatic cholestasis of pregnancy EASL guidelines aid risk stratification

Ms Nina Rodriguez and Dr Tatyana Kushner confirm that the 2023 EASL guidelines can help risk stratify patients with intrahepatic cholestasis of pregnancy.
Unmet needs in late-onset genetic cholestasis: an expert discussion

This CME-accredited expert discussion aims to highlight the unmet needs in late-onset genetic cholestasis and provide guidance on the use of genetic testing in the diagnostic workup and initial management steps for the different genotypes, with reference to key trials and updates from The Liver Meeting 2024: American Association for the Study of Liver Diseases (AASLD).
EASL guidelines direct genetic cholestatic liver management

An EASL expert panel has developed clinical practice guidelines for the management of progressive familial intrahepatic cholestasis and other genetic cholestatic liver diseases.