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Primary biliary cholangitis
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Updates on IBAT inhibitors from EASL 2025

  • PBC, Video

Dr Richard Thompson and Dr Verena Keitel-Anselmino discuss the latest updates on IBAT inhibitors from EASL 2025, including their potential use in PBC patients based on promising phase I and II trial results.

This video offers subtitles in English, French, German, Italian, and Spanish, which can be enabled using the subtitle icon  in the video player.

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  • News article
  • AASLD 2023

Adding bezafibrate to OCA shows treatment promise for PBC

Combining obeticholic acid with bezafibrate 400 mg/day shows therapeutic potential in patients with primary biliary cholangitis in two phase 2 trials.
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  • News article
  • AASLD 2023

Denosumab performs well against bisphosphonate for PBC-related osteoporosis

Denosumab is comparable to bisphosphonates for treating osteoporosis in patients with primary biliary cholangitis, but with fewer adverse effects.
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  • News article
  • AASLD 2023

Positive RESPONSE for seladelpar in patients with PBC

RESPONSE trial findings show seladelpar improves markers of disease activity and reduces pruritus in patients with primary biliary cholangitis.
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  • News article
  • AASLD 2023

ELATIVE: Elafibranor shows treatment efficacy in patients with PBC

ELATIVE trial shows that elafibranor significantly improves biochemical response in patients with primary biliary cholangitis with anti-pruritic benefits.
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  • News article
  • AASLD 2023

Complete biochemical and POISE response seen with second-line OCA in real-world setting

Obeticholic acid positively affects liver function among patients with primary biliary cholangitis in the second-line treatment setting.
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  • Video
  • AASLD 2023

Gideon Hirschfield highlights noteworthy findings on PBC

Dr Gideon Hirschfield discusses some of the highlights on primary biliary cholangitis from The Liver Meeting 2023, with a focus on the RESPONSE trial of seladelpar.
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  • Video
  • AASLD 2023

Kris Kowdley’s analysis of breakthrough research on PBC

Dr Kris Kowdley comments on some of the key data in primary biliary cholangitis, presented at The Liver Meeting 2023, including the ELATIVE trial involving elafibranor.
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  • Video
  • AASLD 2023

Andreas Kremer discusses advances in second-line obeticholic acid

Prof. Andreas Kremer provides his insights on studies on second-line obeticholic acid presented at The Liver Meeting 2023: its use in a real-world setting and as combination therapy with bezafibrate.
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This program is made possible thanks to an independent educational grant from Ipsen.

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